Selected Publications
Signaling mechanisms of cancer progression:
Tang X, Sun Z, Runne C, Madsen J, Domann F, Henry M, Lin F, Chen S. A critical role of Gβgamma in tumorigenesis and metastasis of breast cancer, J Biol Chem. 2011 April 15;286(15):13244-13254. PMID:21349837. PMCID: 3075671.
Muniz VP, Barnes JM, Paliwal S, Zhang X, Tang X, Chen S, Zamba G, Cullen JJ, Meyerholz DK, Meyers S, Davis JN, Grossman SR, Henry MD, Quelle DE. The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis, Mol Cancer Res. 2011 July;9(7):867-877. PMID:21636682. PMCID: 3140613.
Xie Q, Klesney-Tait J, Keck K, Parlet C, Borcherding N, Kolb R, Li W, Tygrett L, Waldschmidt T, Olivier A, Chen S, Liu GH, Li X, Zhang W. Characterization of a novel mouse model with genetic deletion of CD177, Protein & cell. 2015;6(2):117-26. PMID:25359465. PMCID: PMC4312768. doi: 10.1007/s13238-014-0109-1.
Zhang L, Blackwell K, Workman LM, Chen S, Pope MR, Janz S, Habelhah H. RIP1 Cleavage in the Kinase Domain Regulates TRAIL-Induced NF-κB Activation and Lymphoma Survival, Mol Cell Biol. 2015;35(19):3324-38. PMID:26195820. PMCID: PMC4561728.
Ye Y, Tang X, Sun Z, Chen S. Upregulated WDR26 serves as a scaffold to coordinate PI3K/AKT pathway-driven breast cancer cell growth, migration and invasion, Oncotarget. 2016;7(14):17854-69. PMID:26895380. PMCID: PMC4951255. doi: 10.18632/oncotarget.7439.
Paudyal P, Xie Q, Vaddi PK, Henry MD, Chen S. Inhibiting G protein βgamma signaling blocks prostate cancer progression and enhances the efficacy
of paclitaxel., Oncotarget. 2017 May 30;8(22):36067-36081. PMID:28415604. PMCID: PMC5482639. doi: 10.18632/oncotarget.16428.
Molecular mechanisms of obesity and diabetes:
Sun Z, Runne C, Lin F, Chen S. The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein, Cell Signal. 2012 December;24(12):2349-2359. PMID:22940628. PMCID: 3771542.
Ye Y, Sun Z, Guo A, Song LS, Grobe J, Chen S. Ablation of the Gbeta3 gene does not affect blood pressure or metabolism, but cause bradycardia in mice, Cell Signal. 2014;26(11):2514-2520. PMID:25093805. PMCID: 4160384. doi: 10.1016/j.cellsig.2014.07.030.
Qian Q, Zhang Z, Orwig A, Chen S, Ding WX, Xu Y, Kunz RC, Lind NRL, Stamler JS, Yang L. S-Nitrosoglutathione Reductase Dysfunction Contributes to Obesity-Associated Hepatic Insulin Resistance via Regulating Autophagy, Diabetes. 2018 February 1;67(2):193-207. PMID:29074597. doi: 10.2337/db17-0223.
Function and regulation of WD40 repeat proteins:
Chen* S, Lin F, Shin ME, Wang F, Shen L, Hamm* HE. RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma. *Corresponding authors, Mol Biol Cell. 2008 September;19(9):3909-3922. PMID:18596232. PMCID: PMC2526680. *co-corresponding authors.
Sun Z, Tang X, Lin F, Chen S. The WD40-repeat protein WDR26 binds Gβγg and promotes Gβγ-dependent signal transduction and leukocyte migration, J Biol Chem. 2011 December 23;286(51):43902-43912. PMID:22065575. PMCID: 3243526.
Sun Z, Smrcka AV, Chen S. WDR26 functions as a scaffolding protein to promote Gβgamma-mediated PLCβ2 activation in leukocytes, J Biol Chem. 2013 June 7;288(23):16715-16725. PMID:23625927. PMCID: 3675605. doi: 10.1074/jbc.M113.462564.
GPCR signaling-regulated cell migration:
Runne C, Chen S. PLEKHG2 Promotes Heterotrimeric G Protein βgamma-Stimulated Lymphocyte Migration via Rac and Cdc42 Activation and Actin Polymerization*. Mol Cell Biol. 2013 November;33(21):4294-4307. PMID:24001768. PMCID: 3811901. doi: 10.1128/MCB.00879-13. *Recommended by Faculty 1000.
Edvardson S, Wang H, Dor T, Atawneh O, Yaacov B, Gartner J, Cinnmon Y, Chen S*, Elpeleg O*. Microcephaly-dystonia due to mutated PLEKHG2 with impaired actin polymerization. Neurogenetics. 2016;17(1):25-30. PMID:26573021. PMCID: [PubMed - in process]. doi: 10.1007/s1004/-015-0464-y. *co-corresponding authors.
Lin F, Sepich DS, Chen S, Topczewski J, Yin C, Solnica-Krezel L, Hamm H. Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements, J Cell Biol. 2005 June 6;169(5):777-87. PMID:15928205. PMCID: 2171618.
20. Lin F, Chen S, Sepich DS, Panizzi JR, Clendenon SG, Marrs JA, Hamm HE, Solnica-Krezel L. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton, J Cell Biol. 2009 March 23;184(6):909-921. PMID:19307601. PMCID: 2664974.
Xu H, Echemendia N, Chen S, Lin F. Identification and expression patterns of members of the protease-activated receptor (PAR) gene family during zebrafish development, Dev Dyn. 2011 January;240(1):278-287. PMID:21181945. PMCID: 3258453.
Xu H, Kardash E, Chen S, Raz E, Lin F. Gβγ signaling controls the polarization of zebrafish primordial germ cells by regulating Rac activity, Development. 2012 January;139(1):57-62. PMID:22096073. PMCID: 3231772.
Xi H, Ye D, Behra M, Burgess S, Chen S, Lin F. Gβ1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium, Dev Biol. 2014 January;385(2):316-27. PMID:24201188. PMCID: 4134875. doi: 10.1016/j.ydbio.2013.10.027.
Mechanisms and function of GPCR signaling:
Chen S, Xu M, Lin F, Graham RM. Dominant-negative activity of the α1Β-adrenergic receptor induced by a signal-inactivating point mutation, EMBO J. 2000;19(16):4265-4271. PMID:10944109. PMCID: PMC302026.
Ding J, Guzman JN, Tkatch T, Chen S, Goldberg JA, Eberg PJ, Levitt P, Wilson CJ, Hamm HE, Surmeier DJ. RGS4-dependent attenuation of M(4) autoreceptor function in striatal cholinergic interneurons following dopamine depletion, Nat Neurosci. 2006;9(6):832-842. PMID:16699510. doi: 10.1038/nn1700.
Chen S, Hamm HE. DEP domains: More than just membrane anchors, Dev. Cell. 2006 October 1;11(4):436-8. PMID:17011483. doi: 10.1016/j.devcel.2006.09.011.