Welcome to the Chen lab!
Our research is focused on the function and signal transduction mechanisms of G protein coupled receptors (GPCR) in immune cell migration, metabolism and cancer development. Ongoing projects include 1). Multifaceted functions of WD40 repeat proteins in immune cell homing, liver metabolism, and prostate and breast cancer development; 2). Role of GPCRs in HER2+ breast cancer development; 3). Targeting cancer stem cells; 4). Identification of novel molecular determinants of endocrine therapies in cancer via an in vivo CRISPR-based screen. The ultimate goal of our research is to identify novel therapeutic targets for immune disorders, cancer, obesity and diabetes.