Key Publications

  • Tang X, Sun Z, Runne C, Madsen J, Domann F, Henry M, Lin F, Chen S.:  A critical role of Gbg in tumorigenesis and metastasis of breast cancer. J Biol Chem. 286:13244-13254, 2011. PMCID: PMC3075671

  • Sun Z, Tang X, Lin F, Chen S. The WD40-repeat protein WDR26 binds Gbg and promotes Gbg-dependent signal transduction and leukocyte migration. J Biol Chem. 2011 December 23;286(51):43902-43912. PMID:22065575. PMCID: 3243526.

  • Sun Z, Smrcka A.V., Chen S.: WDR26 functions as a scaffolding protein to promote Gbg-mediated PLCb2 activation in leukocytes. J Biol. Chem. 288:16715-16725, 2013.  PMCID: PMC3675605

  • Ye Y, Tang X, Sun Z, Chen S.: Upregulated WDR26 serves as a scaffold to coordinate PI3K/AKT pathway-driven breast cancer cell growth, migration, and invasion. Oncotarget 7(14):17854-69, 2016.  PMCID: PMC4951255

  • Lyu C, Ye Y, Lensing M, Wagner K, Weigel R, Chen S.: Targeting Gi/o protein-coupled receptor signaling blocks HER2-induced breast cancer development and enhances HER2-targeted therapy. JCI Insight. 2021; 6(18):e150532.doi: 10.1172/jci.insight.150532.
  • Lyu C, Bhimani A, Draus W, Weigel R, Chen S. Active Gαi/o mutants accelerate breast tumor metastasis via the c-Src pathway. Mol cell Biol, 2023, 43.12.650-663.
  • Vaddi PK, Stamnes MA, Cao H, Chen S. Elimination of SOX2/OCT4-associated prostate cancer stem cells blocks tumor development and enhances therapeutic response. Cancers. 2019;11(9):pii:E1331. PMID:31500347. PMCID: 6769476. doi: 10.3390/cancers11091331.
  • Lyu C, Ye Y, Weigel R, Chen S. Blocking Gi/o-coupled signaling eradicates cancer stem cells and sensitizes breast tumors to HER2-targeted therapies to inhibit tumor relapse. Cancers 2022, 14(7), 1719
  • Lyu C, Vaddi PK, Elshafae S, Pradeep A, Ma D, Chen S. Unveiling RACK1: a key regulator of the PI3K/AKT pathway in prostate cancer development. Oncogene, 2025, 44(5): 322-335. PMID: 39537875.

  • Lyu C, Yang L, Chen S. A Dual-Compartment Scaffolding Role for RACK1 in Hepatic Glucagon Signaling and Gluconeogenesis. Cell Mol Gastroenterol Hepatol. 2026, 20(2): 101666. PMID:41115526. PMC12718467.

Complete List of Published Work in MyBibliography:  https://www.ncbi.nlm.nih.gov/myncbi/songhai.chen.1/bibliography/public/